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IC‐P‐066: Relationship between Microstructural Degeneration of the Corpus Callosum, White Matter Hyperintensities, and Motor Function in Cognitively Intact Elderly
Author(s) -
Silbert Lisa,
Perkins Louie,
Kaye Jeffrey A.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.081
Subject(s) - corpus callosum , hyperintensity , white matter , fractional anisotropy , fluid attenuated inversion recovery , diffusion mri , psychology , cardiology , leukoaraiosis , magnetic resonance imaging , finger tapping , nuclear medicine , medicine , neuroscience , audiology , radiology
sclerosis CC atrophy has been associated with white matter pathology. Previous findings from the Leukoaraiosis And DISability (LADIS) study have indicated a similar association in non-disabled elderly subjects. However, longitudinal studies are lacking. The aim of the present study was to investigate the effect of Age-Related White Matter Changes (ARWMC) at baseline on CC tissue loss over time. Methods: In total 639 subjects with ARWMC were included in the LADIS study. Subjects underwent MRI scans at baseline and follow-up. Based on baseline MRI scans, ARWMC load was rated using Fazekas scale, which divides patients into 3 groups (mild, moderate, severe). The CC was outlined, quantified and subdivided into 5 subregions at baseline and follow-up. CC atrophy was calculated by subtracting baseline measures from follow-up measures. A total of 396 subjects had undergone MRI follow-up scans, of which 39 were excluded due to poor scan quality leaving 357 patients included in the present study. One-way ANCOVA was used to test for differences between Fazekas scale groups in total CC area tissue loss. For subregional areas, repeated-measures ANCOVA was carried out. Age was entered as covariate. Post-hoc testing using unpaired ttest was conducted to further elucidate any significant differences. Results: Subjects did not differ between Fazekas rating groups with regards to tissue loss of the total CC. Furthermore no difference in CC subregional tissue loss was found between groups. Conclusions: The present results indicate that ARWMC load at baseline does not predict CC tissue loss over a three year period of follow-up.