Premium
IC‐P‐021: Vasogenic edema of grey matter (VEG), a syndrome with Reversible Diffusion Weighted MRI changes, distinct from Posterior Reversible Encephalopathy Syndrome (PRES) and Anoxic Cerebral Ischemia
Author(s) -
Nair Anil K.,
Singh Jasmeet,
Westwood Andrew,
Gupta Apar
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.036
Subject(s) - fluid attenuated inversion recovery , medicine , posterior reversible encephalopathy syndrome , white matter , edema , ischemia , grey matter , magnetic resonance imaging , cerebral edema , hypertensive encephalopathy , radiology , cardiology , blood pressure
showed a negative association restricted to the right occipital horn in PDMCI (pcorrected1⁄4 0.02). Abeta42 showed a negative association restricted to the occipital horns in PDMCI (left pcorrected 1⁄4 0.02, right pcorrected 1⁄4 0.03) and the frontal horns in PDCN (left pcorrected 1⁄4 0.07, right pcorrected 1⁄4 0.02). T-tau and p-tau showed no significant associations with the lateral ventricles. Conclusions: Our results suggest that CSF biomarkers traditionally associated with Alzheimer’s disease (AD) show selective associations with structural brain changes in PD. Increased t-tau levels correlate with hippocampal atrophy while CSF levels of several Abeta species show a correlation with ventricular enlargement. The changes observed in AD are severe tau-associated hippocampal degeneration and amyloid-associated cortical and global brain atrophy. Here we find similar evidence in PD. Our findings suggest that some pathophysiologic events may be common to both disorders.