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IC‐P‐007: Correlation of the AD8: an Informant‐Based Dementia Screening Tool with Amyloid Imaging and CSF Biomarkers of Alzheimer Disease
Author(s) -
Galvin James E.,
Fagan Anne M.,
Holtzman David M.,
Storandt Martha,
Mintun Mark A.,
Morris John C.
Publication year - 2010
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2010.05.022
Subject(s) - dementia , biomarker , medicine , oncology , disease , psychology , biochemistry , chemistry
contrast sensitivity (mean deviation, MD; pattern standard deviation, PSD), 110 threshold measures from 55 retinal regions of each eye, and demographic and cognitive performance variables were compared between groups using ANCOVA, covaried for age at exam, gender, and years of education. The relationships between global GMD, MD, and PSD were assessed using SPM5. Results: Significant differences across groups were detected in FDT-2 measures of overall and local contrast sensitivity, including both MD and PSD, and in 36 right eye retinal regions and 48 left eye retinal regions (p < 0.05 to p < .0001, Figure 1). AD and MCI patients demonstrated the greatest reduction in contrast sensitivity relative to HCs, with CC participants showing an intermediate level of impairment. MD and PSD were significantly related to hippocampal GMD in the left and bilateral hippocampi, respectively (p < 0.01 (unc.), Figure 2). Conclusions: Contrast sensitivity, as measured by the FDT-2 system, is reduced in patients with AD and MCI and may represent a novel and complementary biomarker for detecting and monitoring AD-related neurodegeneration. IC-P-007 CORRELATION OF THE AD8: AN INFORMANTBASED DEMENTIA SCREENING TOOL WITH AMYLOID IMAGING AND CSF BIOMARKERS OF ALZHEIMER DISEASE