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P4‐347: Genetic Analysis Of The Polymorphisms In The Beta And Gamma Secretase Complex And Its Association With Alzheimer's Disease In Mexican Patients
Author(s) -
CamposPeña Victoria,
MenaMontes Beatriz,
Gómez Rocio,
MenaBarranco Francisco,
Meraz Rios Marco Antonio
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.07.145
Subject(s) - senile plaques , amyloid precursor protein secretase , dementia , amyloid precursor protein , disease , alzheimer's disease , single nucleotide polymorphism , biology , population , amyloid (mycology) , amyloid beta , neuroscience , gene , genetics , medicine , pathology , genotype , environmental health
neurofibrillary tangles. Over the past two decades, positron emission tomography (PET) tracers have been developed for in vivo imaging of AD pathology. Of these ligands, [C]PIB and [F]FDDNP have been used most widely. [C]PIB was designed to measure the amount of fibrillar Ab deposits while [F]FDDNP has been reported to label not only amyloid but also other proteins including neurofibrillary tangles. As these two PET ligands are currently considered potential surrogate markers of disease, investigating associations with the hallmark symptom of AD, cognitive impairment, is essential. Objective: To investigate the relationship between [C]PIB and [F]FDDNP binding using positron emission tomography (PET) and measures of cognitive performance in patients with Alzheimer’s disease (AD), mild cognitive impairment (MCI) and controls. Methods: Twelve AD patients, 13 MCI patients and 15 controls were included in this study. Paired [C]PIB and [F]FDDNP scans were performed in all subjects. Global cortical binding potential (BPND) was calculated using parametric images of BPND. Cognitive functions were assessed using a battery of neuropsychological tests. Associations between [C]PIB and [F]FDDNP binding with cognitive measures were assessed using linear regression analyses. Results: Adjusted for age, sex and diagnosis, higher global [C]PIB binding was associated with lower scores on delayed recall of the Rey Auditory Verbal Learning Task (RAVLT) (standardized b1⁄4-0.46, p1⁄40.003). Higher global [F]FDDNP binding was associated with worse performance on immediate and delayed recall of RAVLT (standardized b1⁄4-0.34, p1⁄40.02 and b1⁄4-0.27, p1⁄40.02). No relationship was found for either ligand with impairment on cognitive tests other than memory. Within diagnostic groups, higher [C]PIB binding was correlated with lower scores on delayed recall of RAVLT in MCI patients only. Higher global [F]FDDNP binding was correlated with lower scores on immediate recall of RAVLT in AD patients. Conclusion: Binding of both ligands was related to memory impairment, but not to impairment in other cognitive domains. [C]PIB is especially associated with memory at the stage of MCI while [F]FDDNP has strongest value in patients with AD.