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P4‐282: Changes In Erythrocyte Deformability In Alzheimer's Disease: A Role For Nitric Oxide Synthase
Author(s) -
Misiti Francesco,
Sampaolese Beatrice,
Clementi M. Elisabetta,
Giardina Bruno
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.07.063
Subject(s) - nitric oxide , peptide , acetylcholinesterase , amyloid beta , chemistry , nitric oxide synthase , red blood cell , biochemistry , amyloid (mycology) , medicine , endocrinology , biology , enzyme , inorganic chemistry
Background: Until few years ago, most studies of Alzheimer's disease (AD) investigated the effects of this syndrome in the CNS. Only recently, several evidences suggest that many abnormalities in vascular could be responsible for the AD. In particular, the reduced deformability of erythrocytes is one of the most suspected events associated to vascular abnormalities in AD. At this regard NO was proposed to be a regulatory factor of RBC mechanical properties since inhibitors of endogenous NO synthesis induce decreased erythrocyte deformability.