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Making sense of dementia: Understanding among Indigenous Australians
Author(s) -
Garvey G.,
Simmonds D.,
Clements V.,
O'Rourke P.,
Sullivan K.,
Gorman D.,
Curnow V.,
Wise S.,
Beattie E.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.07.013
Subject(s) - indigenous , dementia , residence , disease , gerontology , public health , promotion (chess) , medicine , psychology , sociology , nursing , demography , political science , ecology , biology , pathology , politics , law
ical testing before and 3 and 12 months after CABG surgery was analyzed for Ab42 and Ab40. Patients were classified as having pre-existing cognitive impairment (PreCI) if cognitive function was decreased in two or more tests compared with a healthy control group, and postoperative cognitive dysfunction (POCD) was defined as a decline in two or more tests compared with the group mean baseline score. Results: PreCI was present in 117 patients (35.2%) and POCD in 40 (12%) at 3 months and 41 (13%) at 12 months after surgery. Both plasma Ab42 and Ab40 levels assessed before the CABG surgery were significantly decreased in patients who later had POCD at 3 months. Conclusions: Decreased preoperative plasma levels of Ab42 and Ab40 in patients who exhibit POCD at 3 months suggest that POCD at this time might share a common pathology with MCI/AD. This process might be exacerbated by anesthesia.