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S5‐02‐01: Actions of apoE and cholesterol in abeta metabolism
Author(s) -
Zerbinatti Celina
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.577
Subject(s) - apolipoprotein e , endocrinology , medicine , cholesterol , receptor , lipid anchored protein , liver x receptor , chemistry , biology , biochemistry , nuclear receptor , autophagy , disease , apoptosis , gene , transcription factor
addition, we measured markedly elevated CSF aSyn levels (300.0 þ/ 248 pg/ul) in 14-3-3-positive Creutzfeldt-Jakob disease (CJD) patients that significantly differed from all other groups (CJD versus NCO, p < 0.001). Using the same technique, we also measured the concentration of total aSyn in serum and plasma from healthy subjects, which measured 15.0 þ/ 0.9 and 45.0 þ/ 1.4 pg / ul, respectively. Conclusions: Our data confirm the previous finding that aSyn is present in adult human CSF. In a cross-sectional study of 67 donors with neurodegeneration and 13 NCO subjects, we recorded a pathological rise of CSF aSyn in all definite CJD cases and observed the lowest mean concentration in our donors with advanced PD. Mean CSF aSyn concentrations were comparable among the AD and NCO groups, whereas the values for probable and definite DLB cases ranged between those for AD and PD. Ongoing studies seek to identify the source(s) and variants of CSF aSyn in living donors, and to further examine its utility in the diagnosis of neurodegenerative syndromes.