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O4‐05‐07: Subhippocampal dysfunction as a clinical marker of incipient Alzheimer's disease
Author(s) -
Didic Hamel Cooke Mira,
Barbeau Emmanuel J.,
Felician Olivier,
Guedj Eric,
Ranjeva JeanPhiliphe,
Cozzone Patrick,
Ceccaldi Mathieu
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.555
Subject(s) - psychology , dementia , neuroscience , neuroimaging , neuropsychology , temporal lobe , atrophy , context (archaeology) , parietal lobe , audiology , medicine , disease , cognition , pathology , paleontology , epilepsy , biology
Results: Our findings suggest that possession of the e4 and e2 alleles confer adverse and beneficial neuropsychological effects, respectively, in the AIBL cohort, but that there are differences between these alleles with respect to dose-response outcomes and cognitive domain specificity. The influence of the e4 allele appears to be greater in magnitude than the e2 allele. Of note, the effects of these genetic factors are present i) in both AD and non-AD cases and ii) after controlling in AIBL participants for premorbid intellectual capacity, age and self-reported symptoms of depression and anxiety. Conclusions: These findings have important implications in characterizing the role of genetic factors influencing the manifestation of neurocognitive characteristics that have been associated diagnostically with the onset of AD.