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O4‐05‐04: Identification of prodromal Alzheimer's with serial neuropsychological tests
Author(s) -
Orgogozo JeanMarc,
Amieva Helene,
Le Goff Melanie,
Carcaillon Lise,
Jacqmin Helene,
Auriacombe Sophie,
Dartigues JeanFrançois
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.552
Subject(s) - dementia , neuropsychology , episodic memory , psychology , audiology , recall , cognitive decline , cognition , medicine , psychiatry , disease , cognitive psychology
memory complaints, and the APOE e4 carriage was best in predicting incident probable Alzheimer dementia (R 1⁄4 0.42). An area under the ROC curve of 0.91 was reached. The model achieved a positive predictive value of 23.3% and a negative predictive value of 98.7% and is able to predict Alzheimer dementia with a sensitivity of 82.8% and specificity of 82.4%. Conclusions: AD can be predicted by neuropsychological instruments measuring episodic memory and motor speed. 98.7% of subjects at age 75 years could be predicted as remaining nondemented at age 80 years. Whether the age associated cognitive slowing expressed as a decline in motor speed is a predictor of AD needs further inverstigation.