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O3‐03‐06: How to define the cognitive impairment in Mild Cognitive Impairment: Comparison of different neuropsychological classification methods using data from the Sydney Memory and Ageing Study
Author(s) -
Kochan Nicole,
Brodaty Henry,
Crawford John,
Slavin Melissa,
Low LeeFay,
Trollor Julian,
Draper Brian,
Reppermund Simone,
Kang Kristan,
Sachdev Perminder
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.444
Subject(s) - concordance , dementia , cognition , neuropsychology , psychology , memory impairment , audiology , psychomotor learning , population , cognitive impairment , cohort , neuropsychological test , clinical psychology , medicine , psychiatry , disease , environmental health
predicted dementia in cohort 1930. Conclusions: Preliminary analyses suggest that it might be difficult to detect predictors of dementia in later born cohorts using non-memory specific psychometric tests. older adults (125 AD, 125 aMCI and 176 controls with normal cognition) were recruited. Both BMI and WC decreased significantly across the normal, aMCI and AD groups (dementia diagnostic group: p for trend <0.001 and 0.016 respectively, 1-way ANOVA). After adjustment for significant confounders, multivariate general linear model analyses showed that the dementia diagnostic group (AD/aMCI/NC) was a significant independent predictor of both the late-life BMI and late-life WC (p 1⁄4 0.002 and 0.018 respectively). Conclusions: Late-life BMI and WC progressively decrease in older adults with normal cognition, aMCI and AD. Low late-life BMI and WC represent potentially useful pre-clinical markers of aMCI and AD.