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O3‐03‐02: Neuropsychiatric predictors of progression from Mild Cognitive Impairment to Alzheimer's Disease
Author(s) -
Palmer Katie,
Di Iulio Fulvia,
Caltagirone Carlo,
Spalletta Gianfranco
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.440
Subject(s) - apathy , depression (economics) , hazard ratio , neuropsychiatry , medicine , psychiatry , disease , dementia , proportional hazards model , cognitive impairment , confidence interval , pediatrics , economics , macroeconomics
were analyzed for folate and carotenoids. The association between nutritional factors and non-dementia was analyzed by logistic regression and adjusted for age, education and apoE4. Results: The risk of ASYMAD was higher among subjects with elevated folate (odds ratio 1⁄4 1.15/unit of folate, lower CL 1⁄4 1.025) and beta-carotene (odds ratio 1⁄4 1.05/unit of beta-carotene, lower CL 1⁄4 1.001) levels than in subjects who suffered from dementia. The mean concentration of folate and beta-carotene was 16.4 and 23.6 in non-demented subjects, and 12.6 and 19.1, respectively in demented subjects. Conclusion: Blood concentrations of the nutritional factors, folate and beta-carotene, were associated with non-dementia in the presence of AD pathology. Folate has several functions which may influence the clinical expression of AD. Also, folate and beta-carotene concentrations may be biomarkers for the intake of diets that are high in leafy green vegetables, and which may contribute several nutritional factors with beneficial effects in the maintenance of neural tissues.