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O2‐01‐08: Effects of ApoE genotype but not of FAD mutation status in BOLD activation during a novelty encoding task
Author(s) -
Ringman John M.,
Medina Luis D.,
Schaffer Barbara,
Agudelo Yaneth Rodriguez,
Varpetian Arousiak,
MaciasIslas Miguel Angel,
Cummings Jeffrey L.,
Bookheimer Susan Y.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.323
Subject(s) - psen1 , apolipoprotein e , novelty , functional magnetic resonance imaging , genotype , neuroscience , blood oxygen level dependent , mutation , psychology , medicine , presenilin , disease , genetics , alzheimer's disease , biology , gene , social psychology
(4.1.0). VBM (SPM5 and DARTEL) and Freesurfer were used to assess effects within grey matter at each voxel and vertex respectively (FDR corrected, q<0.05). Linear regression was used to assess the individual and independent effects of gender, age and TIV. Results: Age, gender, and TIV were individually associated with all ROI volumes (see table) except age and caudate, age and amygdala and gender and hippocampus. Age and TIV had independent associations with all ROIs. Gender had an independent effect only on whole brain (p<0.001). The 95% CIs of the slope of TIV and ROIs never contained 1 indicating that dividing by TIV is not appropriate head-size adjustment. Age had a widespread negative association with thickness and volume throughout the cortex which survived gender and TIV adjustment (see figure). TIV was associated with increased thickness in the right-sided occipital lobe but not after age and gender adjustment. TIV had a large positive association with grey matter volume, which remained following age and gender adjustment. Gender had some effect on thickness in the left hemisphere (women>men) and a large effect on volume (men>women) but these were lost following TIV and age adjustment. Conclusions: Age has a large effect on results generated by all analysis techniques. Head-size adjustment is unnecessary for thickness analysis should gender and age be used, but is required for volume analyses. Gender-adjustment may be necessary for thickness studies and some ROI analysis but not for VBM should TIV and age be used.