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IC‐P‐171: The relevance of cholinergic‐catecholaminergic interaction (cognitive processes and oxidative stress) in Alzheimer's disease
Author(s) -
Ciobica Alin,
Hritcu Lucian,
Artenie Vlad,
Manuela Padurariu,
Bild Walther
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.144
Subject(s) - glutathione peroxidase , agonist , endocrinology , cholinergic , homovanillic acid , medicine , pilocarpine , chemistry , superoxide dismutase , oxidative stress , pharmacology , psychology , neuroscience , receptor , serotonin , epilepsy
subjects after a complete description of the study. All subjects underwent a clinical, neuropsychological, psychiatric, and socio-demographic evaluation, including the fulfill of the Charlson Comorbidity Index (CCI) that encompasses 19 medical conditions; Mini Mental State Examination (MMSE), Clock Drawing Test, Montgomery Asberg Depression Rating Scale (MADRS); Geriatric Depression Scale (GDS), Pfeffer, and BEHAVE. Results: From the original sample: 11 subjects (13.1%, aged 75.54 6 2.31 years) fulfilled DSM-IV criteria for dementia, 50 subjects (61.7%) presented at least one comorbid clinical condition, and 35 (44.3%) presented major depressive symptomatology. Even though, we did not observed significant difference regarding to the presence of clinical comorbidities in demented and non-demented subjects, there was a trend in the prediction of higher CCI score and MMSE scores (p1⁄4 0.08). Logistic regression also showed that dementia was strongly associated to depressive symptomatology, increasing age, impairment in daily life activities and presence of behavioral pathology. In the same direction, depressive symptomatology was directly correlated to the presence of behavioral pathology (p1⁄4 0.006). Conclusions: In the evaluation of an elderly subject the assessment of comorbidities should be accounted to the presence of depressive symptomatology. As depressive symptoms is a potentially modifiable factor it is important to recognize and treat, therefore resulting in better quality of life and lower level of morbidity in the elderly.