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IC‐P‐155: Reduced frontal oxygenation during a verbal fluency test in patients suffering from Alzheimer's disease
Author(s) -
Langer Julia B.M.,
Schecklmann Martin,
Polak Thomas T.,
Leonhard Christine,
Leitner Thomas,
Rothenhoefer Martina,
Fallgatter Andreas J.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.128
Subject(s) - verbal fluency test , prefrontal cortex , audiology , neuropsychology , psychology , dorsolateral prefrontal cortex , neuroscience , medicine , cardiology , cognition
and right lateral parietal, temporal and frontal regions. Word recall was associated with the bilateral cingulate and medial frontal gyrus and the right superior frontal and superior temporal gyrus. Word recognition was correlated with the cingulate gyrus bilaterally, the right cuneus and thalamus as well as the left superior longitudinal fascicle. Verbal fluency was associated with the cingulate gyrus, the medial frontal gyrus and the cuneus as well as left temporal and right frontal and parietal regions. Naming was correlated with FA in the anterior cingulate, the medial frontal, parahippocampal and lingual gyrus, the cuneus and the left parietal lobe. Constructional praxis depended on integrity of the uncus, the parahippocampal and lingual gyrus, the cuneus and lateral temporo-parietal regions. Conclusions: Our results suggest that fiber connections between several key regions are involved in cognitive decline in AD: First, an underlying cognitive network as basis for integrated cognitive function, possibly reflecting the default mode network whose deactivation precedes the performance of specific cognitive tasks; second, additional brain areas that are involved in specific cognitive functions. As a first study, our data may guide future research to determine the interaction between cognition and white matter connectivity.