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IC‐P‐138: Diagnostic Utility of Diffusion Tensor Imaging and Deformation‐Based Morphometry for the Assessment of Alzheimer's Disease
Author(s) -
Teipel Stefan J.,
Friese Uwe,
Meindl Thomas,
Herpertz Sabine,
Reiser Maximilian,
Hampel Harald
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.110
Subject(s) - diffusion mri , parahippocampal gyrus , corpus callosum , fractional anisotropy , receiver operating characteristic , white matter , magnetic resonance imaging , spatial normalization , medicine , atrophy , neuroscience , nuclear medicine , pathology , radiology , psychology , temporal lobe , epilepsy
parahippocampal gyrus (PIP) as the seed mask in the probabilistic fiber tracking and implementing quantitative analysis to the overall connectivity maps. 2. Fiber tracking from the dorsal caudate (DCA) to the PIP but avoiding the thalamus to compare across-group difference of this fiber pathway in the optimal template selected based on the fractional anisotropic skeleton images. Results: For the fiber tracks that passes from the PIP to the whole brain, group analysis of 10 AD subjects compared to 10 NC subjects didn’t show any statistical significant difference between these two groups (p 1⁄4 0.05, paired t-test). The connections from the left DCA to the left PIP after excluding the thalamus showed that there were slight bilateral differences in the sub-cortical areas near the caudate and close to the left hypothalamus when comparing AD with the NC groups. Conclusions: Our study suggest that while the memory reserve through the PIP connectivity maps is not different between early AD and NC, the ability to form new ‘‘correct’’ information through the specific error check pathway from the DCA to the PIP might be impaired in the early AD.