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IC‐P‐123: A direct comparison of ventricular volumes derived from 1.5 Tesla and 3.0 Tesla MRI in 115 ADNI participants
Author(s) -
Nestor Sean M.,
Borrie Michael,
Smith Matthew,
Bartha Robert
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.095
Subject(s) - magnetic resonance imaging , nuclear medicine , medicine , neuroimaging , alzheimer's disease neuroimaging initiative , cognitive impairment , cardiology , psychology , radiology , disease , psychiatry
disturbances of the anterior part of the hippocampus are associated with impaired episodic memory function we correlated several global and regional hippocampal diffusivity and hippocampal volume measurements in 12 patients with early AD (MMSE 25.3 6 1.8) with the cognitive performance of the patients. Results: Compared to a group of 16 ageand educationmatched normal controls all global and regional hippocampal volumes were significantly decreased bilaterally in early AD with a pronounced volume difference within the anterior hippocampus (hippocampus head). Early AD patients showed significant diffusivity increases only within the hippocampus head bilaterally. Episodic memory performance (delayed verbal recall test) correlated most strongly with increased left hippocampal head diffusivity of the patients group (r 1⁄4 0.72, p 1⁄4 0.008). Significant correlations of the verbal delayed recall test with decreased hippocampal volume in the body-tail regions bilaterally (left: r1⁄4 0.59, p1⁄4 0.045; right: r1⁄4 0.58, p1⁄4 0.048) could also be found in the patient group. Conclusions: Our findings suggest that elevated diffusivity is a sensitive and early marker of functional relevant structural disturbances of the hippocampus in AD. Moreover, increases of cross-sectional left anterior hippocampal diffusivity seem to be more closely related to verbal memory impairment than global or regional hippocampal volume reductions. Additionally, these data support the assumption that the anterior hippocampus contains necessary neuronal substrates of episodic memory function.