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IC‐S1‐03: PET Amyloid imaging and cognition in patients with Alzheimer's disease, Mild Cognitive Impairment (MCI) and healthy controls: a European multicenter study
Author(s) -
Nordberg Agneta,
Rinne Juha,
Drzezga Alexander,
Brooks David J.,
Vandenberghe Rik,
Perani Daniela,
Almkvist Ove,
Scheinin Noora,
Grimmer Timo,
Okello Aren,
Van Laere Koen,
Hinz Rainer,
Carter Stephen F.,
Kalbe Elke,
Herholz Karl
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.05.006
Subject(s) - neuropsychology , pittsburgh compound b , cognition , verbal memory , psychology , cognitive impairment , medicine , audiology , pathology , cardiology , neuroscience
were further classified according to the presence or absence of an ApoE4 allele and by their subjective memory complaints (MC). All participants underwent a comprehensive neuropsychological examination, a MRI and a PiB-PET scan. Correlational analyses were performed between the different study outcomes. Results: Cortical PIB binding was markedly elevated in all AD patients except one. MCI subjects presented either an ‘‘AD-like’’ (63%) or normal pattern. Cortical PiB retention was abnormal in 34% of HC and its prevalence increased with age. HC with subjective memory complaints carrying an ApoE4 allele had significantly higher Ab burdens than non ApoE4 carriers. Conclusions: Phase I of the AIBL study has established the foundations for the longitudinal assessment of Ab burden in HC, MCI and AD. This will assist the development of techniques for early detection of AD while providing a cohort suitable for targeted early intervention studies.