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P3‐205: Effect of puromycin sensitive aminopeptidase overexpression on TAU protein metabolism in vivo
Author(s) -
Kudo Lili C.,
Vi Nancy,
Lau Kimbley,
Parfenova Liubov,
Hui Maria,
Gray Michelle,
Yang X.William,
WiedauPazos Martina,
Hui KoonSea,
Karsten Stanislav
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.978
Subject(s) - neuroprotection , genetically modified mouse , in vivo , neurodegeneration , transgene , puromycin , aminopeptidase , biology , western blot , blot , glutamine , endocrinology , medicine , microbiology and biotechnology , biochemistry , pharmacology , protein biosynthesis , amino acid , leucine , disease , gene
protein hyperphosphorylated on the AD associated epitopes. Conclusions: Our data showed that tau protein truncation leads to development of neurofibrillary pathology similar to human tauopathies and AD. The results indicate that accumulation of aberrant tau protein species within the transgenic rat cortical neurons and human neuroblastoma cells can be prevented by treatment with inhibitors of HSP90.