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P3‐285: Antibody immune response in cynomolgus monkeys following treatment with the active Aß immunotherapy CAD106
Author(s) -
Imbert Georges,
Marrony Severine,
Ulrich Peter,
Goldsmith Paul
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.956
Subject(s) - titer , antibody , immunotherapy , antibody titer , immune system , immunology , monoclonal antibody , immunoglobulin g , pharmacodynamics , virology , medicine , chemistry , pharmacology , pharmacokinetics
terms of their efficacy or to discover new ones. Methods: In pursuit of better caspase-3 inhibitors, a quantitative structure-activity relationship (QSAR) analysis was performed on a series of caspase-3 inhibitors using molecular modeling software WIN CAChe 6.1 and statistical software STATISTICA. Results: The present study results in partition coefficient (log P), conformational energy (CME), and lowest unoccupied molecular orbital energy (ELUMO) as optimum physico-chemical properties which determine the caspase-3 inhibitory activity. Conclusions: On the basis of above study a new series of caspase-3 inhibitors has been designed with greater caspase-3 inhibitory activity. After synthesizing these compounds, it can be hypothesized that biological evaluation of these compounds would prove to be effective in addressing neurodegenerative disorders.