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P4‐095: The prevalence and impact of type 2 diabetes in mild cognitive impairment and Alzheimer's disease
Author(s) -
Hodges Elise K.,
Ryan Kelly A.,
Persad Carol C.,
Barbas Nancy R.,
Heidebrink Judith L.,
Talton Kenya,
Ramirez Gabriela,
Giordani Bruno J.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.864
Subject(s) - medicine , disease , diabetes mellitus , cognitive impairment , cognition , alzheimer's disease , type 2 diabetes mellitus , type 2 diabetes , demographics , gerontology , psychiatry , demography , endocrinology , sociology
Background: There has been interest in an unusual clinical phenomenon, in which a patient draws a complex figure in a position that is grossly rotated relative to the original. This implicates theories of objective recognition and visuospatial function. It has been claimed that rotated drawings was related to the dysfunction of parieto-occipital lobe or frontal lesions. However, the range of perfomance as well as anatomical correlation remains obscure. Methods: 76 year old woman with right caudate nucleus infarction case. Results: A 76-year-old, uneducated woman visited to our hospital because she had wandering on the familiar road to the daughter’s house 2 days ago. She had no history of impairment with cognition and active daily living (ADL). She had recognized hypertension for twenty years. On neurological examination, she was alert and no deficit of motor and sensory system on grossly except cognition found. Her performance on neuropsychological tests was impaired in frontal executive function and verbal memory as well as copying of Rey-Osterrieth Complex figure. The figure was rotated in copying tasks by 90-degree conterclockwise. On Brain Magnetic Resonance Image (MRI), acute infarction in the head of right caudate nucleus region was observed. After 2 month later, rotation recorvered at follow up neuropsychological evaluation. Conclusions: Many connections exist between frontal lobe and basal ganglia. Our result suggests that frontal lobebasal ganglia dysfunction by caudate infarction can be concerned for rotated drawing.