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P4‐083: The influence of lipid profile on neuropsychological test in community‐dwelling normal elders
Author(s) -
Moon Seok Woo,
Kim Tae Ho,
Choi Jin Yong,
Lee Nam Jin
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.852
Subject(s) - neuropsychology , neuropsychological test , lipid profile , medicine , triglyceride , test (biology) , lipoprotein , high density lipoprotein , cholesterol , cognition , psychology , endocrinology , biology , psychiatry , paleontology
Background: It is important to know whether subtle cognitive decline shown by older adults is an early sign of dementia or a healthy aging process. Methods: The database of Prevalence Study 1998 and those of Incidence Study 2003 were retrospectively analyzed. The 200 adults who were assessed as Clinical Dementia Rating (CDR) 0 in the two surveys during a 5-year period (1998 to 2003) were classified into four age groups based on the age at the baseline in 1998, i.e. 65-69 years, 70-74 years, and 75 years and over groups. Cognitive functions were assessed using the Cognitive Abilities Screening Instrument (CASI). It consists of nine cognitive domains, i.e. remote memory, recent memory, attention, concentration and mental manipulation, orientation, figure copying, abstraction and judgment, list-generating fluency, and language. Two-way ANOVA with the covariance of educational level was performed to show the time differences of each cognitive domain. Results: All CASI domains showed no time differences between 1998 and 2003 except for orientation. Conclusions: We found that the healthy older adults assessed as CDR 0 showed stable cognitive performances except for time orientation. This means that recent memory impairment, even a slight decline, may be an early sign of dementia which could be discriminated from the healthy aging process.