Premium
P4‐070: False recognition in Alzheimer's disease and mild cognitive impairment
Author(s) -
Koide Reiko,
Ishii K.,
Kinjo Hikari,
Takeda T.,
Tomidokoro Y.,
Tamaoka A.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.839
Subject(s) - wechsler adult intelligence scale , wechsler memory scale , audiology , psychology , dementia , cognition , hippocampus , montreal cognitive assessment , alzheimer's disease , mini–mental state examination , medicine , cognitive impairment , disease , cardiology , psychiatry , neuroscience
Background: False Recognition, usually called False Alarm (FA), is a common type of memory distortions in which an individual incorrectly claims to have encountered a novel object or event. Although the hippocampus has been shown to be the responsible brain region, few studies have reported its clinical manifestation in the progression of Alzheimer’s disease (AD). We analyzed the data on FA responses in the word recognition task in Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-Cog) in patients with AD, with mild cognitive impairments (MCI), and normal controls. Methods: The data of 28 patients with probable AD, 28 patients with MCI, and 58 age-matched controls, were analyzed. AD was diagnosed according to the criteria of the National Institute of Neurological and Communicative Disorders and Stroke (NINCDS) and the Alzheimer’s Disease and Related Disorders Association (ADRDA). Patients with MCI were diagnosed on the basis of showing intact daily activity, normal Mini-Mental State Examination (MMSE, 30-25), and deviated memory reduction (less than 85) in at least one index of Wechsler Memory Scale Revised (WMS-R). MRI and SPECT were administered to MCI patients. They showed reduced cerebral perfusion in the right or left hippocampus, or in bilateral parietal lobes and posterior or anterior cingular gyrus. One of them showed slight lacuna infarctions, though applied to the above criteria. Normal control subjects were attending a municipal physical fitness program for senior citizens. All of them showed normal MMSE (28-30), and normal memory scores in all WMS-R indexes. Results: FA was observed in patients with AD more frequently than patients with MCI and normal controls at a statistically significant level (p<0.000). No statistically significant difference was found between the groups of MCI and controls. FA was observed in 27 out of 28 AD patients, but with one exception, none was observed in MCI or in normal controls. Conclusions: The presence of FA in the word recognition test of ADASCog could be used as one of the markers to detect the onset of AD in the progression of the disease from MCI to AD, although it was not sensitive to detect its prodromal phase.