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P4‐064: Study on the performance of behavioural assessment of the dysexecutive syndrome (BADS) in healthy individuals, mild cognitive impairment and Alzheimer's disease
Author(s) -
Armentano Cristiane G.C.,
Porto Claudia S.,
Brucki Sonia M.D.,
Nitrini Ricardo
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.833
Subject(s) - dysexecutive syndrome , psychology , neuropsychology , executive functions , cognition , rating scale , dementia , verbal fluency test , audiology , clinical dementia rating , disease , cognitive impairment , clinical psychology , psychiatry , medicine , developmental psychology
Background: Neurosychological tests or scales such as MMSE (Mini-Mental State Examination) and CDR (Clinical Dementia Rating) are employed to classify the population into normal subjects, subjects with mild cognitive impairment (MCI) and patients with Alzheimer’s disease (AD). For example, in an international project, the Alzheimer’s Disease Neuroimage Initiative (ADNI), the three groups were classified by the neuropsychologocal tests as follows. 1. Subjects with MMSE scores between 24 and 30 are classified as Normal or MCI subjects. In contrast, subjects with MMSE scores between 20 and 26 are classified as mild AD. (Note that subjects with scores between 24 and 26 are not exactly diagnosed). 2. Subjects with a CDR global score of 0 are classified as Normal subjects. In contrast, subjects with a CDR global score of 0.5 are as MCI subjects or mild AD, and those with a CDR global score greater than 0.5 are as mild AD. Methods: This study aims to clarify whether a short form of MMSE or that of CDR can classify subjects into the three groups in the same way as the full form of MMSE (10 categories) or that of CDR (6 categories). The screening and baseline data of the 804 ADNI subjects were analyzed to examine accuracies of the various short forms. Results: It was shown that a short form of MMSE excluding the 3 categories such as Naming, Reading and Writing from the full form can discriminate the three groups with accuracy of 99.1%. It was revealed that a short form of CDR (Memory category only) can discriminate Normal from the others with accuracy of 100%. Conclusions: Hence, the combination of the short form of MMSE and that of CDR enables us to classify subjects precisely into the three groups more quickly than the full forms.