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P4‐053: Systematic review and meta‐analysis of the accuracy of the eurotest for the detection of dementia
Author(s) -
EspejoMartinez Beatriz,
CarneroPardo Cristóbal,
MontoroRíos M. Teresa
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.822
Subject(s) - meta analysis , dementia , homogeneous , population , diagnostic accuracy , medicine , systematic review , psychology , medline , mathematics , disease , environmental health , combinatorics , political science , law
and abnormal function. Consistent with this hypothesis, assessment of 9-10 month old mice revealed a further decline in LTP magnitudes (WT: 171.967.7%, n1⁄47; Het: 136.766.2%, n1⁄48). Behavioral studies were conducted in parallel to ascertain whether these synaptic deficits correlated with age-related cognitive impairments measured in the Morris water maze, a hippocampal-dependent cognitive assay. Surprisingly, no difference between WT and Het animals was found at any age in MWM performance. Conclusions: These results suggest that overexpression of normal tau protein negatively influences hippocampal synaptic properties, but retain sufficient capacity for performing a hippocampal-dependent behavioral test.