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P4‐121: Genome‐wide association study of Alzheimer's with psychotic symptoms
Author(s) -
Hollingworth Paul,
Sims Rebecca,
Abraham Richard,
Harold Denise,
Gerrish Amy,
Hamshere Marian,
Lovestone Simon,
Brayne Carol,
Gill Michael,
Lawlor Brian,
Passmore Peter,
Nothen Markus,
Mayer Wolfgang,
Livingston Gill,
Bass Nicolas,
Goate Alison,
Younkin Steve,
AlChalabi Ammar,
Gwilliam Rhian,
Morgan Kevin,
Deloukas Panos,
Holmans Peter,
O'Donovan Michael,
Owen Michael,
Williams Julie
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.789
Subject(s) - genome wide association study , single nucleotide polymorphism , psychosis , genetic association , alzheimer's disease , population , medicine , dementia , disease , genetics , psychiatry , biology , genotype , gene , environmental health
the study will be presented at ICAD 2009. Conclusions: Previous evidence suggests that psychosis susceptibility or modifier genes may act across the traditional ‘‘disease divide’’. Identification of genetic variation associated with psychosis in AD will further our understanding of the disease mechanisms which underlie this sub-type of AD and may have implications for other neurodegenerative disorders where psychotic symptoms are common.