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P4‐186: The effect of Tubulin Polymerisation Promoting Protein (TPPP/p25) overexpression on the aggregation of alpha‐synuclein
Author(s) -
Botond Gergo,
Kovacs Gabor G.,
Laszlo Lajos,
Prechl Jozsef,
Kurucz Istvan,
Budka Herbert,
Ströbel Thomas
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.753
Subject(s) - alpha synuclein , microtubule , microbiology and biotechnology , tubulin , cytoplasm , western blot , phosphorylation , intracellular , chemistry , biology , biochemistry , medicine , parkinson's disease , disease , gene
iv) cognitive status by water maze and fear conditioning tests. Results: Sadenosylmethionine is able to revert (or prevent) the observed exacerbation of Alzheimer-like features induced by B vitamin deficiency in TgCRND8 mice: SAM/SAH ratio decrease, PSEN1 and BACE over-expression, amyloid processing and deposition. Conclusions: These findings confirm and extend our previous observation on the role of one-carbon metabolism and of methylation reactions in particular, and highlight the molecular mechanism connecting this metabolism with AD onset and progression. Possible intervention on one-carbon metabolism, and the use of SAM in particular, for the treatment of AD finds an evident rationale on the basis of these results.