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P4‐182: X chromosome premature centromere division in neurons of Alzheimer patients
Author(s) -
SpremoPotparevic Biljana,
Zivkovic Lada,
Djelic Ninoslav,
PlecasSolarevic Bosiljka,
Smith Mark A.,
Bajic Vladan
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.749
Subject(s) - interphase , centromere , mitosis , biology , chromosome , cell cycle , cell division , neuroscience , fluorescence in situ hybridization , cerebral cortex , cell , pathology , microbiology and biotechnology , genetics , medicine , gene
interaction of Grb2-SH2 with AICD and the consequent movement of the complex mediated by the SH3 domains. En route this complex is localized in vesicular structures inside the cell. Conclusions: Grb2 mediated rerouting of APP/AICD traffic might have long term implications in AD pathogenesis. Especially since SH3 domain of Grb2 is supposed to regulate the movement by interacting with cytoskeletal proteins, it would be interesting to know the fate of the traffic in a degenerating neuron. Further, the differential role of N-terminal and C-terminal SH3 domain in this trafficking is also to be deciphered.