Premium
P2‐265: Effect of APP 5‐mer peptide on production and differentiation of cultured embryo hippocampal neural stem cells originated from SD rats
Author(s) -
Meng Yan,
Zhang JingYan,
Wang Rong,
Chen Bing
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.579
Subject(s) - neurogenesis , neurosphere , neural stem cell , hippocampal formation , microbiology and biotechnology , biology , dentate gyrus , hippocampus , stem cell , neurotrophin , clone (java method) , subgranular zone , peptide , chemistry , in vitro , neuroscience , adult stem cell , biochemistry , subventricular zone , gene , receptor , endothelial stem cell
also reversed the spatial and working memory deficit induced by MK-801 and scopolamine in Morris water maze, NORT and radial arm maze task. The effective dose range of SUVN-502 in the these animal models was between 3 to 10 mg/kg p.o. SUVN-502 enhanced brain acetylcholine and glutamate levels in rat ventral hippocampus and frontal cortex SUVN-502 has high oral bioavailability and good brain penetration index. A double-blind, placebo-controlled, randomized, ascending single and multiple-dose study was conducted with healthy male subjects. SUVN-502 was safe and well tolerated in humans at all single and multiple doses tested. Conclusions: SUVN-502 has the potential for best in the class candidate with a favorable pharmacokinetics, safety and toxicology profile. SUVN-502 completed human Phase I clinical studies and is ready to enter clinical proof of concept studies for cognitive dysfunction associated with Schizophrenia and Alzheimer’s diseases.