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P2‐234: The interactions of trospium and galantamine with late onset Alzheimer disease and urinary incontinence
Author(s) -
Isik Ahmet Turan,
Bozoglu Ergun,
Celik Turgay,
Doruk Huseyin
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.547
Subject(s) - galantamine , nocturia , medicine , mirabegron , urinary incontinence , solifenacin , urinary system , urology , disease , overactive bladder , donepezil , dementia , alternative medicine , pathology
a ligand on AChE (enzyme kinetics). Results: The phytoconstituent of ethyl acetate extract of C. asiatica in HPLC revealed the abundant presence of a triterpene: asiatic acid. The IC50 value of asiatic acid on AChE was 85mM. Asiatic acid do not have cytotoxic effect as revealed by MTT assay. Under stress, the AChE activity in hippocampus cell line is increased concomitant to neurite formation results in decreased viability of cells. Asiatic acid reverse the above phenomena so that viability of cells restored. Conclusions: The study revealed the asiatic acid as a potent inhibitor of AChE, further it did not show any cytotoxicity on hippocampus cell line. The report of asiatic acid as a cognitive enhancer, use of AChE inhibitors in the ailment of AD for symptomatic memory restoration together with our finding asiatic acid inhibition on AChE, suggest the possible use of asiatic acid as a drug of choice in AD treatment. Thus this study finds the phytoconstituent asiatic acid as a potential template for designing new, selective and powerful anti Alzheimer’s drugs.