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P2‐118: Dietary patterns associated with Alzheimer's disease ‐ A population based study (BERCAL)
Author(s) -
Gustaw Katarzyna A.,
Włodarek Dariusz,
Leszczyńska Bożena,
Petot Grace
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.429
Subject(s) - varimax rotation , population , disease , medicine , demography , risk factor , gerontology , environmental health , cronbach's alpha , psychometrics , clinical psychology , sociology
normal cognition by consensus. Participants also completed a 128-item food frequency questionnaire and nutrient intakes were estimated using the Food Processor SQL system. Results: Among 1,264 non-demented subjects who completed the questionnaire, 157 (12%) received a diagnosis of MCI. Using the lowest tertile as reference, there were significant associations between MCI and increasing intake of PUFA (middle tertile: odds ratio [OR] 1⁄4 0.88, 95% confidence interval [CI] 1⁄4 0.56, 1.38; upper tertile: OR 1⁄4 0.42, 95% CI 1⁄4 0.22, 0.80; p for trend 1⁄4 0.01), linoleic acid (middle tertile: OR 1⁄4 0.84, 95% CI 1⁄40.54, 1.32; upper tertile: OR 1⁄4 0.41, 95% CI 1⁄4 0.21, 0.77; p for trend 1⁄4 0.01), and omega-6 fatty acids (middle tertile: OR 1⁄4 0.90, 95% CI 1⁄4 0.57, 1.40; upper tertile: OR 1⁄4 0.40, 95% CI 1⁄4 0.21, 0.76; p for trend 1⁄4 0.007) after adjustment for sex, age, years of education, and total energy intake. We observed no significant association with omega-3 fatty acids but the OR decreased with increasing intake (middle tertile: OR1⁄4 0.97, 95% CI1⁄4 0.62, 1.53; upper tertile: OR1⁄4 0.61, 95% CI1⁄4 0.33, 1.12; p for trend1⁄4 0.15). Conclusions: In this sample of 70 89 year olds, there is an inverse cross-sectional association between PUFA, linoleic acid, omega-6 fatty acids and MCI. These findings are consistent with studies that have reported similar inverse associations for cognitive impairment and dementia.