Premium
P2‐106: Echocardiography vortex formation time reveal cardiac diastolic transmitral flow dysfunction in Alzheimer's disease patients
Author(s) -
Roher Alex E.,
Belohlavek Marek,
Maarouf Chera L.,
Kokjohn Tyler A.,
Garami Zsolt,
Beach Thomas G.,
Sabbagh Marwan N.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.417
Subject(s) - cardiology , medicine , parasternal line , diastole , ejection fraction , hemodynamics , perfusion , doppler echocardiography , blood flow , pathological , heart failure , blood pressure
Background: The interactive effects of aerobic-related physical activity (AR-PA) with Apolipoprotein E (APOE) genotypes on cognitive performance, are yet to be examined in a nationally representative US sample. Whether this relationship is influenced by age, is a subject of much debate. We test the hypothesis that AR-PA is associated with enhanced cognitive performance, and that this relationship is differentially influenced by APOE genotypes and age, using a nationally representative US sample (The Third National Health and Nutrition Examination Survey (NHANES III, 1988-1994)). Methods: We analyzed data from 7159 persons, age 60 who participated in NHANES III. From this sample, 1799 older American men and women had data on AR-PA, Short Portable Mini Mental Status Examination (Sp-MMSE) and important co-variates, and were genotyped at the APOE locus. Self-reported socio-demographics and biochemical measurements were also obtained. Results: In the entire sample, AR-PA associated with enhanced cognitive function, and this relationship was differentially influenced by APOE genotypes, with non-E4 carriers and E4 heterozygote performing better than E4 homozygote. Initial regression analysis adjusted for age, ethnicity, severe chronic medical illness, lean body mass (LBM), and education showed statistically significant association of AR-PA with cognitive function (age-group 60-69: b1⁄40.5260.18; P1⁄40.007); and (age-group 70: b1⁄40.5660.23; P1⁄40.022), respectively, in non-E4 but not in E4 carriers (age-group 60-69: b1⁄40.0160.2352; P1⁄40.95); and (age-group 70: b1⁄40.5860.35; P1⁄40.109), respectively. With additional adjusted for mobility limitation, the association of AR-PA with cognitive performance in non-E4 carriers though became slightly attenuated, remained statistically significant in age-group 60-69 (b1⁄40.4360.16; P1⁄40.014) and tended towards significance in the older age-group 70 (b1⁄40.3760.23; P1⁄40.117). Whereas mobility limitation (proxy measure for sedentary lifestyle) showed a strong but negative association with cognitive function (b1⁄4 -0.7860.16; P < 0.001) in non-E4 carriers aged 70, the difference did not reach significance level in the remaining groups. Conclusions: In a nationally representative sample, AR-PA associated with better cognitive performance, an effect that predominated in non-E4 APOE genotype group and likely influenced by age. Collectively, our observation adds to growing evidence that increased levels of ARPA may offer an important intervention strategy to attenuate cognitive decline as the population ages.