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P2‐094: Association between insulin resistance and cognitive function in mild cognitive impairment
Author(s) -
Park HyunYoung,
Lee HakSeung,
Chang Hyuk,
Kim YoSik,
Cho KwangHo
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.404
Subject(s) - insulin resistance , medicine , dementia , insulin , diabetes mellitus , neuropsychology , endocrinology , cognition , type 2 diabetes , disease , psychiatry
with CDRS score 0.5, who did not meet the DSM-IV dementia criteria, were selected and diagnosed as MCI. 38 subjects with CDRS score 0.5 or more, who met the DSM-IV dementia criteria were diagnosed as AD. Old age, low levels of education, histroy of head trauma were associated significantly with AD (p<0.01, p<0.01 p<0.05). Interestingly, the proportion of subjects on DM medications was significantly different among the three groups (p<0.05). There were significant differences in the mean score of MMSE-KC and GDS-K among normal, MCI and the AD group (p<0.01, p<0.01). These scores were significantly correlated with each other in this study population (p<0.05). There was a significant correlation between the MMSE-KC score and serum total cholesterol and triglyceride levels in MCI group (p<0.05, p<0.05), but not in normal controls and AD group. Finally, we found that the mean score of Hachinski Ischemic Scale was significantly different among three groups (p<0.05). Conclusions: Our results strongly suggested that many vascular risk factors are associated with cognitive impairments in MCI and AD patients. In this study,serum lipid levels were associated with global cognitive dysfunction in MCI group. We confirmed that DM is a risk factor for MCI and AD in our Korean population.