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P2‐082: Defining mild cognitive impairment: Disparity of incidence and prevalence estimates with variable operationalized definitions
Author(s) -
Ward Alex,
Michels Shan L.,
Cedarbaum Jesse,
Arrighi H. Michael
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.392
Subject(s) - incidence (geometry) , medicine , dementia , cognitive impairment , concordance , demography , observational study , sample size determination , population , prevalence , gerontology , cognition , epidemiology , pediatrics , psychiatry , statistics , disease , sociology , optics , physics , mathematics , environmental health
dementia). Results: Baseline prevalences in this sample were 6.31% for dementia, 11.9% for aMCI, and 6.6% for naMCI. The overall annual incidence rates were 3.1% for dementia, 4.0% for aMCI, and 3.7% for naMCI. The annual rates of change from aMCI and naMCI to dementia are 14.9% and 3.7% respectively. The table shows that the incidence rates for dementia and aMCI increase with age while rates for naMCI do not. Parametric survival models confirmed no increase in naMCI incidence rates with age (p1⁄40.78). Conclusions: Dementia and aMCI incidence shows the expected increase with age. naMCI does not behave like a pre-dementia condition in that its incidence rates do not increase with age and the overall rate is not associated with an increased risk of incident dementia.