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P2‐075: Lower body mass index associated with higher CSF levels of tau pathology in Alzheimer's Disease
Author(s) -
Ewers Michael,
Faluyi Yetunde,
Buerger Katharina,
Teipel Stefan J.,
Bokde Arun L.W.,
Hampel Harald
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.385
Subject(s) - cerebrospinal fluid , body mass index , medicine , apolipoprotein e , dementia , endocrinology , gastroenterology , senile plaques , pathology , disease , alzheimer's disease
carer. Consent to fasting blood sampling was obtained in 413 subjects. Serum glucose was determined using an enzymatic/colorimetric method. Results: Participants were on average 87.1 6 4.3 years old, 72.0% women, and had a mean 5.4 6 2.6 years of education. During follow-up about one third of the participants developed dementia. A history of diabetes was present in 12.3% of dementia incident cases and in 12.4% of the non-demented elderly (p1⁄4 0.96). Mean glucose concentrations at baseline did not significantly differ between subjects with incident dementia (93.8 6 26.0 mg/dL) and nondemented elderly (98.2 6 37.2 mg/dL), (p 1⁄4 0.17). Conclusions: The present prospective population-based study failed to demonstrate a significant association between diabetes or glucose concentration and dementia in the very old.