Premium
P2‐032: Neural correlates of focused attention in cognitively normal older adults and patients with Alzheimer's disease
Author(s) -
R. Bowes Jennifer,
Klar Salman,
Stroman Patrick W.,
Johnsrude Ingrid,
Garcia Angeles
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.341
Subject(s) - stroop effect , psychology , audiology , cognition , neural correlates of consciousness , developmental psychology , cognitive psychology , neuroscience , medicine
10 preclinical AD (MMSE: 28.961.1, CDR: 0) were 2.0560.30 and 1.8860.27, respectively. The cortical PIB retention was significantly correlated to MMSE scores in these groups (r1⁄4-0.27, n1⁄494, P<0.01). On FDG PET 3D-SSP images, in contrast, twenty-four (51%) of AD dementia showed a significant reduction of glucose metabolism in temporo-parietal cortex (metabolic AD-pattern). In prodromal AD only two patients (6%) had classic metabolic AD-pattern. There was no hypometabolism in any of cortical areas in preclinical AD. The increased PIB bindings did not correlate to comparable metabolic decreases in cortical areas of these groups. Conclusions: This diagnostic framework with brain amyloid deposition, in clinical different stage of AD, would allow an earlier and more specific AD diagnosis and play an important role of anti-amyloid strategies.