Premium
P2‐030: 3‐D mapping of verbal fluency performance in amnestic mild cognitive impairment and Alzheimer's disease
Author(s) -
Li Tao,
Zhang MeiYan,
Liao Jing,
Chang Daniel,
Yuan Huishu,
Su MinYing,
Yu Xin,
Wang Huali
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.339
Subject(s) - verbal fluency test , audiology , lateralization of brain function , psychology , voxel , neuropsychology , fluency , inferior parietal lobule , cognition , cognitive psychology , medicine , neuroscience , radiology , mathematics education
impairment, non demented elderly (CIND) from a community-based sample. The study of neuropsychiatric syndromes instead of separate neuropsychiatric symptoms may point to a common neurobiological pathogenesis, or may respond to the same treatments. Methods: The dementia epidemiologic study was performed in the urban area of São Paulo. Thirteen patients with AD, 11 with CIND and 13 normal individuals were evaluated. The HMRS was performed in the right temporal, left parietal and medial occipital region studying the metabolits: N-acetylaspartate (NAA), creatine (Cr), choline (Cho) and myo-inositol (mI). The neuropsychiatric symptoms were assessed with the Neuropsychiatric Inventory (NPI) and classified in neuropsychiatric syndromes (hyperactivity, psychosis, affective symptoms and apathy) in accordance with the results from the European Alzheimer Disease Consortium. The neuropsychiatric syndromes were correlated with the H-MRS metabolities. Results: Parietal mICr was correlated positively with hyperactivity and apathy. Temporal mICr was correlated negatively with psychosis in patients with AD (Spearman’s coefficient; p 0,05). On the other hand, in the CIND group, occipital NAACr was correlated negatively with hyperactivity and psychosis and temporal NAA and mI were correlated negatively with apathy (Spearman’s coefficient; p 0,05). The comparison between the average NPI scores in each group (AD, CIND and normal individuals) showed significantly differences between elderly controls and AD patients on the apathy scores. Conclusions: The results suggest that neuropsychiatric symptoms can be associated with specific metabolic alterations measured by H-MRS in patients with AD and CIND.