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P2‐010: Evaluation of hippocampal structures in mild cognitive impairment and Alzheimer disease by 3 tesla MRI
Author(s) -
Takahashi Junko,
Takahashi Satoshi,
Yonezawa Hisashi,
Kudoh Masako,
Obara Satoko,
Shibata Toshihide,
Suzuki Masako,
Terayama Yasuo
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.319
Subject(s) - entorhinal cortex , white matter , hippocampal formation , dentate gyrus , cognitive impairment , nuclear medicine , magnetic resonance imaging , neuroscience , hippocampus , medicine , psychology , cognition , radiology
MRI scan and standardized uptake ratio values (SUVR) for all VOI were obtained using the cerebellar cortex as reference region. Results: AD patients displayed higher cortical [18F]BAY 94-9172 retention (2.060.3) than HC (1.360.2). In AD patients, cortical SUVR test-retest variability was 6.8% (range 0.6-12.2%, median 8.2%). In HC cortical SUVR test-retest variability was 2.9% (range 0.1-9.0%, median 2.8%). Combined testretest variability was 4.7%. Variability was higher in smaller VOI. Conclusions: Overall, test-retest variability is similar to the one reported for PiB (Lopresti et al., 2005). Cortical test-retest variability in AD patients was higher than in HC, and not affected by the range of specific activity likely to be seen in clinical practice.