Premium
P1‐276: Ethical issues in recruitment of at risk healthy individuals to clinical trials involving greater than minimal risk
Author(s) -
Pierce Robin
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.284
Subject(s) - normative , informed consent , dementia , intervention (counseling) , psychological intervention , ethical issues , population , clinical trial , medicine , psychology , affect (linguistics) , disease , nursing , alternative medicine , engineering ethics , environmental health , political science , pathology , law , communication , engineering
of the ten patients we also recorded the electroencephalogram (EEG). EEG were recorded at T0 and at T1 for 5 five minutes through 21 electrodes following the 10-200 International System with a sampling frequency of 1024 Hz, a bandpass of 0,5-500 Hz, and a sensibility of 7 uV/mm. EEG were analyzed in the frequency domain (power spectrum and coherence). Results: AtDCS improved the accuracy of the word recognition task (p1⁄40.0068), CtDCS significantly worsened it (p1⁄40.011), and StDCS left it unchanged. tDCS left the visual attention RTs unchanged. AtDCS and CtDCS produced specific, differential, and significant effects over the mean power spectral density, the interand intra-hemispheric coherence in all the electrodes (p<0.0001). In particular, whereas AtDCS increased the occipital intra-hemispheric coherence in the gamma band (p1⁄40,047), CtDCS increased it in the d band (p1⁄40,021). Conclusions: tDCS delivered over the T-P cortex modulated cortical electrophysiological activity and improved a recognition memory task in patients with probable AD.