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P1‐275: Measurement of cerebrospinal fluid total tau and phospho‐tau in phase 2 trials of therapies targeting Aβ
Author(s) -
Siemers Eric R.,
Dean Robert A.,
Lachno D.R.,
Zajac Joseph J.,
Sethuraman Gopalan,
DeMattos Ronald B.,
May Patrick C.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.283
Subject(s) - medicine , placebo , cerebrospinal fluid , gastroenterology , pathology , alternative medicine
of the ten patients we also recorded the electroencephalogram (EEG). EEG were recorded at T0 and at T1 for 5 five minutes through 21 electrodes following the 10-200 International System with a sampling frequency of 1024 Hz, a bandpass of 0,5-500 Hz, and a sensibility of 7 uV/mm. EEG were analyzed in the frequency domain (power spectrum and coherence). Results: AtDCS improved the accuracy of the word recognition task (p1⁄40.0068), CtDCS significantly worsened it (p1⁄40.011), and StDCS left it unchanged. tDCS left the visual attention RTs unchanged. AtDCS and CtDCS produced specific, differential, and significant effects over the mean power spectral density, the interand intra-hemispheric coherence in all the electrodes (p<0.0001). In particular, whereas AtDCS increased the occipital intra-hemispheric coherence in the gamma band (p1⁄40,047), CtDCS increased it in the d band (p1⁄40,021). Conclusions: tDCS delivered over the T-P cortex modulated cortical electrophysiological activity and improved a recognition memory task in patients with probable AD.