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P1‐146: Hippocampal volume and depressive symptoms: a population‐based neuroimaging study
Author(s) -
Geda Yonas E.,
Weigand Stephen,
Pankratz Ver S.,
Kantarci Kejal,
Roberts Rosebud O.,
Knopman David S.,
Boeve Bradley F.,
Ivnik Robert J.,
Rocca Walter A.,
Jack Clifford,
Petersen Ronald C.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.151
Subject(s) - depression (economics) , neuroimaging , magnetic resonance imaging , population , beck depression inventory , psychology , medicine , cardiology , psychiatry , anxiety , radiology , environmental health , economics , macroeconomics
Background: Subjects with Alzheimer’s disease (AD) experience progressive ventriculomegaly. Normal aging is likewise associated with ventricular enlargement. Here we report on the extent that aging affects lateral ventricle comparisons between subjects with AD, mild cognitive impairment (MCI) and cognitively normal controls (NC). Methods: We used a novel automated ventricular segmentation method paired with the radial distance mapping technique to examine the differences in lateral ventricle shape and size between 33 MCI (mean age 72.666.4 years) and 34 AD (mean age 75.267.9 years) and 43 NC subjects (mean age 66.467.9 years). Mean age was significantly different between the NC and the AD and NC and MCI groups. To examine the aging effect we compared the uncorrected between-group comparison maps to those corrected for age, sex and education and developed a quadratic regression model of the effect of age on the lateral ventricle. Results: The uncorrected NC vs. MCI significance maps revealed extensive bilateral frontal (left p1⁄40.008, right p1⁄40.006), left temporal (left p1⁄40.03) and left occipital horn (left p1⁄40.024) differences between the groups. After correction for age, neither education and sex nor diagnosis effects remained significant. The uncorrected MCI vs. AD significance maps revealed trend-level frontal (left p1⁄40.05; right p1⁄40.07), occipital (left p1⁄40.06, left p1⁄40.05) and temporal horn (left p1⁄40.08, left p1⁄40.07) differences. Age-correction reduced the diagnosis effects to the right temporal (p1⁄40.052) and left occipital horns (p1⁄40.07) only. In the NC vs. AD comparison the uncorrected maps showed significant frontal (left p1⁄40.0001; right p1⁄40.0004) and occipital (left p1⁄40.0016; right p1⁄40.0007) and left temporal horn differences (left p1⁄40.016; right p1⁄40.07). The corrected maps revealed significant diagnosis effects only for the bilateral occipital (left p1⁄40.02; right p1⁄40.013) and right frontal horn (left p1⁄40.057; right p1⁄40.04). A quadratic regression model associating age with ventricular radial distance was highly significant throughout the ventricles (p<0.0001 for all). Conclusions: Age induces highly significant effects on lateral ventricle size. Even when no significant between group-differences were detected (i.e., in the MCI vs. AD comparison), the uncorrected and corrected maps showed substantial differences. Age should therefore always be accounted for analyzing lateral ventricle data. be accounted for analyzing lateral ventricle data.