Premium
P1‐144: Assessment of structural differences in normal aging and Alzheimer's disease: Quantitative and qualitative differences using subjects from the Alzheimer's Disease Neuroimaging Initiative (ADNI)
Author(s) -
Nikelski Jim,
Evans Alan,
Chertkow Howard
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.149
Subject(s) - supramarginal gyrus , white matter , alzheimer's disease neuroimaging initiative , primary motor cortex , atrophy , voxel , insula , neuroimaging , dementia , psychology , voxel based morphometry , audiology , middle temporal gyrus , neuroscience , motor cortex , medicine , pathology , cognition , cognitive impairment , disease , magnetic resonance imaging , radiology , stimulation , functional magnetic resonance imaging
thresholded at p<0.005). Results: Regarding metacognitive measures, less accurate monitoring of one’s general (off-line monitoring) and visual memory performance was significantly associated with elevated PiB uptake in multiple regions in the temporal cortex, frontal cortex, and precuneus/posterior cingulate. No significant association appeared between monitoring accuracy of CVLT or executive test performance and PiB uptake. Regarding objective performance on cognitive tests, PiB uptake was not related to episodic memory measures, however significant associations were observed with executive performance in temporal and frontal regions. Conclusions: The dissociation of relationships between metacognitive monitoring and objective memory abilities with PIB uptake suggests that inability to accurately assess one’s memory capacities may be a relevant predictor of early AD development, perhaps even before the occurrence of memory decline per se. Overall, metacognitive measures may offer insight into the behavioral and pathological changes that occur in aging, as well as embody an interesting clinical index to take into account in the diagnostic process of AD.