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P1‐128: Altered hippocampal network activity links memory deficits and depressive symptoms in amnestic mild cognitive impairment
Author(s) -
Goveas Joseph S.,
Xie Chunming,
Li Wenjun,
Wu Zhilin,
Franczak Malgorzata,
Antuono Piero,
Jones Jennifer,
Li ShiJiang
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.133
Subject(s) - posterior cingulate , psychology , parahippocampal gyrus , audiology , neuroscience , default mode network , gyrus , resting state fmri , anterior cingulate cortex , cognition , temporal lobe , medicine , epilepsy
The pathophysiology of OCD is thought to involve disturbance of the frontalsubcortical circuitry. OCD symptoms has not yet to be directly studies in the neurodegenerative conditions involving behavior changes. To examine regional abnormalities in the brains of dementia patients with OCD symptoms, we assessed the gray matter density using voxel-based morphometry (VBM). Methods: A total of 106 patients diagnosed with one of six neurodegenerative diseases were recruited into the study from the University of California San Francisco Memory and Aging Center. Criteria for including patients were a diagnosis of dementia, the availability of modified Manchester Behavior Questionnaire (MBQ) data and a high quality research MRI scan within 6 months of the modified MBQ assessment. OCD behaviors were assessed using modified MBQ. Covariates-only statistical models were used to show the relationship between OCD symptom scores and gray matter volume. Results: The total OCD symptom score correlated negatively with the volume of both putamen, right middle orbitofrontal gyrus, both anterior cingulate, left insula (p<0.001, uncorrected). No gray matter reductions were associated specifically with the OCD symptom sub-categories. To explore which part of the OCD circuit identified in our results were contributed predominantly by a single diagnostic group, we evaluated unique brain regions associated with OCD total score according to the dementia subtype. Alzheimer’s disease and FTLD including FTD, semantic dementia, primary progressive aphasia did not show unique regions associated with OCD total score (p<0.001, uncorrected). At an uncorrected significance threshold (p<0.001), no gray matter reductions were associated specifically with the OCD behavior sub-categories. Conclusions: Our findings show that the right orbitofrontal, both putamen, both anterior cingulate, and left insula are regions associated with OCD symptoms in dementia patients, but distinct gray matter abnormalities are not associated with the symptom dimensions of OCD. Our results suggest that abnormalities in these area may play an important role in the pathophysiology of OCD in neurodegenerative disease. Further research is necessary to verify neuroanatomic mechanisms for OCD symptoms in patients with neurodegenerative disease.