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P1‐126: Neurophysiology of human memory: the effects of Alzheimer's disease risk factors
Author(s) -
McLaren Donald G.,
Xu Guofan,
Ries Michele L.,
Johnson Sterling C.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.131
Subject(s) - psychology , cognition , default mode network , hippocampus , posterior cingulate , neuroscience , encoding (memory) , apolipoprotein e , memory impairment , audiology , developmental psychology , cognitive psychology , disease , medicine
NJ). FSE qT2 was acquired on a 3T (GE) MRI: (resolution:1.6x1.6x1.6mm ), TR1⁄46000ms, TEs1⁄410/30/60/90/120/150ms. DNA samples were taken for ApoE genotyping. Individual qT2-maps were correlated with cognitive scores using VBA on brain images using SPM2 (UCL, UK). Results: Significant Correlations (p<0.005) were found for Timed action parameters (fig. 1): Thalamus, Pons, Superior & Middle Temporal-gyrus, Cuneus, Precentral gyrus, Cingulate gyrus, Lentiform nucleus, Parahipocmapl-gyrus, Right Postcentral-gyrus, Cingulate gyrus and Precuneus. Verbal tasks (fig. 2): RightMiddle and Right-Superior Frontal-gyrus, Right-Frontal Extra-nuclear areas. Corpus Callosum, Precuneus, Left-Middle and Right-Superior Temporal-gyrus, Left Precentral gyrus. Non-verbal tasks (fig. 3): Middle-Temporal gyri, Precuneus, Left-Cuneus, Left-Superior Temporal-gyrus, Parahippocampalgyrus, Right Lingual-gyrus. Division of task specific areas is indicated in the figures. Conclusions: Generally, the areas found are in accordance with cognitive localization reported in the literature. For timed action parameters, mostly white matter areas correlated. For verbal tasks, both gray matter areas and white matter areas correlated. For non-verbal tasks mostly gray matter areas correlated. We showe that qT2 provide complementary and similar information to DTI and fMRI, but has advantages of short acquisition time, lower susceptibility to artifacts, higher resolution, and more robust statistical significance (less intrinsic noise). In conclusion, though T2 is often overlooked as a tool for studying function in the brain, here we show that qT2 is useful for cognitive localization studies with sufficient inter-subject variability. Additional analysis will include evaluation of ApoE effect on brain structure and qT2 values.