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P1‐124: Correlation between white matter hyperintensities in MRI‐FLAIR and 11C‐PiB PET retention: A new potential for early identification of disease
Author(s) -
Raniga Parnesh,
Villemagne Victor L.,
Fripp Jurgen,
Bourgeat Pierrick,
Acosta Oscar,
Szoeke Cassandra,
Ourselin Sebastien,
Ames David,
Ellis Kathryn A.,
Masters Collin L.,
Salvado Olivier,
Rowe Chris C.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.129
Subject(s) - hyperintensity , fluid attenuated inversion recovery , nuclear medicine , white matter , magnetic resonance imaging , voxel , pittsburgh compound b , partial volume , lesion , medicine , cognitive impairment , radiology , pathology , disease
participant pool (N 1⁄4 163) were excluded from analyses for not meeting full criteria. Neuroimaging data for the current analyses were collected via a 3D, IR-prepped, axial SPGR sequence. Data processing, segmentation, and TBM analyses were carried out using DARTEL in SPM5. Resulting Jacobian determinant maps for each participant (i.e., vector maps of tissue contraction or expansion from the study-specific mean gray matter template) were entered into a voxel-wise multiple regression analysis. Jacobian determinant values and their relationship to APOE genotype were adjusted (controlled) for total gray matter volume, gender, age, and education. Results: Regression results revealed a significant gray matter cluster in the left anterior parahippocampal region that was associated with APOE genotype (120 mm, PFWE-corrected < 0.01). Adjusted Jacobian values for the cluster local maxima and their relation to the four APOE genotypes were plotted, revealing an incremental increase in Jacobian values as a function of genotypic risk. Conclusions: Our results suggest that, even after controlling for total gray matter volume, gender, age, and education, significant differences exist in the regional gray matter of the left parahippocampus as a function of APOE genotype in healthy seniors. Differences in this region appear to scale inversely along a low-tohigh continuum of APOE genotypic risk for late-onset AD.