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Cerebral blood flow in ischemic vascular dementia and Alzheimer's disease, measured by arterial spin‐labeling magnetic resonance imaging
Author(s) -
Schuff Norbert,
Matsumoto Shinji,
Kmiecik Joseph,
Studholme Colin,
Du Antao,
Ezekiel Frank,
Miller Bruce L.,
Kramer Joel H.,
Jagust William J.,
Chui Helen C.,
Weiner Michael W.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1233
Subject(s) - cerebral blood flow , magnetic resonance imaging , dementia , cardiology , hyperintensity , vascular dementia , medicine , atrophy , arterial spin labeling , pathology , disease , radiology
Background Our objectives were to compare the effects of subcortical ischemic vascular dementia (SIVD) and Alzheimer's disease (AD) on cerebral blood flow (CBF), and then to analyze the relationship between CBF and subcortical vascular disease, measured as volume of white‐matter lesions (WMLs). Methods Eight mildly demented patients with SIVD (mean ± SD; aged 77 ± 8 years; Mini‐Mental State Examination score 26 ± 3 years) and 14 patients with AD were compared with 18 cognitively normal elderly subjects. All subjects had CBF measured using arterial spin‐labeling magnetic resonance imaging, and brain volumes were assessed using structural magnetic resonance imaging. Results AD and SIVD showed marked CBF reductions in the frontal ( P = 0.001) and parietal ( P = 0.001) cortices. In SIVD, increased subcortical WMLs were associated with reduced CBF in the frontal cortex ( P = 0.04), in addition to cortical atrophy (frontal, P = 0.05; parietal, P = 0.03). Conclusions Subcortical vascular disease is associated with reduced CBF in the cortex, irrespective of brain atrophy.