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P3‐048: Alzheimer's disease and subcortical dementia may share similar patterns of cognitive deficits in the early stages
Author(s) -
Fukui Toshiya,
Kitamura Mugi,
Hosoda Hiroe,
Bokui Chiyo,
Namasu Kaori,
Okita Kumiko
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1225
Subject(s) - dementia , psychology , dementia with lewy bodies , cognition , audiology , vascular dementia , alzheimer's disease , activities of daily living , disease , medicine , psychiatry
baseline and completed at least one annual clinical follow-up examination. The diagnoses at follow-up were made independently of the previous evaluation. We used Cox proportional hazards modeling to determine if the baseline H MRS metabolites and age-gender-head size adjusted hippocampal volumes (hippocampal-W scores) predict progression to dementia at follow-up. Results: Patients with MCI who underwent imaging did not differ from the parent MCI cohort on demographic aspects, APOE e4 frequency, or cognitive function. Twenty of the 122 MCI patients progressed to dementia after a median (range) of 1.5 (0.9-2.7) years. Lower posterior cingulate gyrus NAA/Cr and hippocampal-W scores at baseline increased the risk of future dementia in MCI. The hazard ratio (95% confidence interval) for an NAA/Cr decrease from 75 to 25 percentile of the cohort was 1.92 (1.0,3.9) (p1⁄40.019), and for a hippocampal-W score decrease from 75 to 25 percentile of the cohort was 1.62 (0.9,2.9) (p1⁄40.053). NAA/Cr and hippocampal-W scores were complementary in predicting risk of dementia in the multi-variable model as demonstrated in the Kaplan-Meier plot (Figure). Conclusions: In agreement with the findings in clinic-based settings, the neuronal integrity marker NAA/Cr levels on H MRS and hippocampal volumes are complementary in predicting the risk of dementia in a populationbased MCI cohort.