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P3‐041: Transthyretin correlated with oxidative stress in Alzheimer's disease pathology: A population‐based study (BERCAL)
Author(s) -
Gustaw Katarzyna A.,
DmoszyńskaGraniczka Magdalena,
Kowalczuk Krystyna,
Kurzepa Jacek,
StryjeckaZimmer Marta
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1218
Subject(s) - transthyretin , oxidative stress , population , medicine , pathogenesis , dementia , disease , endocrinology , pathology , environmental health
hippocampal volume after accounting for outliers (r 1⁄4 -0.663, p1⁄40.026). There was no association between the ceramide levels and other cognitive tests. Conclusions: Our previous results suggest that plasma ceramides are specifically altered in amnestic MCI (aMCI). The present results suggest that plasma ceramides predict a worsening of memory impairment and hippocampal volume loss over 1-year of follow-up. These results suggest that high plasma ceramide levels may be important predictors of progression among aMCI cases, and potentially useful for the purpose of clinical trial enrichment so as to lessen long and costly therapeutic trials in early stages of AD. Further, identifying a blood-based biomarker would be superior to other neuroimaging and CSF biomarkers in terms of costs, invasiveness, and feasibility.