Premium
P3‐083: Alterations in activation between mild cognitive impaired subjects during a working memory task and resting coherent network
Author(s) -
Bokde Arun,
Ewers Michael,
Faluyi Yetunde,
Delaney Catherine,
Khattack Abid,
Collins Ronan,
Kerskens Christian,
Coughlan Tara,
Nibrihain Siobhain,
Daly Ian,
Swanwick Greg,
O'Neill Desmond,
Hampel Harald
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1159
Subject(s) - precuneus , fusiform gyrus , middle frontal gyrus , parahippocampal gyrus , psychology , functional magnetic resonance imaging , default mode network , neuroscience , superior frontal gyrus , episodic memory , audiology , posterior cingulate , middle temporal gyrus , temporal lobe , working memory , inferior temporal gyrus , cognition , medicine , epilepsy
PET and FDG-PET in diagnosing AD. Methods: The diagnosis for MCI and probable AD followed the MCI clinical criteria presented by Petersen et al. (Petersen et al. 1999) and National Institute of Neurological and Communication Disorders, Alzheimer’s Disease and Related Disorders Association (McKhann et al. 1984), respectively. [11C]-BF-227 was synthesized from the precursor by N-methylation in dimethyl sulfoxide using [11C]-methyl triflate. The [11C]-BF-227 PET study was performed using a PET SET-2400 W scanner (Shimadzu Inc., Japan).Cerebral glucose metabolism was measured using 18F-FDG and a PET scanner SET-2400 W. Subjects were scanned in a quiet and dimly-lit room with their eyes closed after at least four hours of food restriction. Results: Patients with MCI subjects showed significantly increased accumulation of [11C]-BF-227 compared to AN in frontal, temporal, parietal, and occipital cortices as well as anterior and posterior cingulate gyrus. On the other hand SUV-R of BF-227 was lower in MCI compared to AD in lateral temporal, parietal, and occipital cortices, posterior cingulate gyrus, and striatum. SUV-R of BF-227 was negatively correlated with that of FDG when we analyzed the data from all the subjects (AN, MCI, and AD) together. The specificity and sensitivity for diagnosis of AD with BF-227 were significantly better than those with FDG-PET. Conclusions: We conclude that BF-227 PET is a useful technology in diagnosing MCI or an early stage of AD with very little invasion. These results indicate that MCI has intermediate retention of 11C-BF-227 between AN and AD indicating that Ab deposition already started in the stage of MCI before dementia symptoms become obvious.