Premium
P3‐078: Predictors of improvement in cognitive ability in Chinese persons with mild cognitive impairment: A 2‐year follow up
Author(s) -
Lam Linda C.,
Tam Cindy W.,
Yeung Grace T.,
Lui Victor W.,
Fung Ada W.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1154
Subject(s) - clinical dementia rating , dementia , verbal fluency test , cognition , medicine , logistic regression , memory clinic , psychology , cognitive impairment , population , neuropsychology , audiology , disease , psychiatry , environmental health
Background: It is well recognized that MCI is a high risk condition for subsequent development of clinical dementia. However, prospective studies all identified that a significant proportion of subjects with MCI do not deteriorate, or even improve. This study examines the two-year course of change in cognitive function in a group of Chinese subjects with mild cognitive impairment (MCI). Methods: 500 Chinese subjects (aged 60 or over) with MCI were recruited from community volunteers and population survey. Amnestic MCI were diagnosed according to the Mayo Clinic criteria, non-amnestic MCI were subjects with global Clinical Dementia Rating (CDR) <1 and >1⁄42 CDR subscale in non-memory domains rated as 0.5 or more. They were followed up at an average of 22(3.8) months. Outcome was defined as either improved (not satisfied criteria for MCI), stable (MCI at follow up) or demented. Results: At follow up, 156(48%) remained stable, 119(36%) improved and 52 (16%) became demented. Amnestic MCI-single domain subjects (66%) were associated with a higher rate of improvement than subjects with amnestic MCI-multiple domain deficits (26%) and nonamnestic MCI(45%)(Pearson Chi square1⁄427.2, p< 0.001). Logistic regression revealed that younger age, better baseline cognitive function (verbal fluency, delayed recall and MMSE scores) were associated with improvement. For the subgroup with amnestic MCI multiple domain deficits, a lack of Apolipoprotein E4 allele were associated with higher proportion of improved outcome status at two years (Pearson chi square1⁄4 3.8, p1⁄40.05). Conclusions: The current study demonstrated that Chinese subjects classified with conventional criteria for MCI concord with other populations in terms of clinical progress. Some subjects with MCI improved with time. A better cognitive function and genetic factors may be associated with higher chance for improvement. It would be important to explore other modulating factors that may influence cognitive deterioration in this group of high risk subjects.