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P3‐150: Histone acetylation enhances neurotrophin expression and synaptic plasticity in aging brain
Author(s) -
XIE CuiWei,
Yin Xiao Feng,
Zeng Yan,
Watson Joseph B.
Publication year - 2009
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2009.04.1125
Subject(s) - long term potentiation , synaptic plasticity , tropomyosin receptor kinase b , schaffer collateral , trichostatin a , histone deacetylase , neuroscience , hippocampal formation , neurotrophic factors , histone deacetylase inhibitor , brain derived neurotrophic factor , histone , neurotrophin , acetylation , chemistry , biology , microbiology and biotechnology , medicine , receptor , biochemistry , gene
FOME scores when compared to those with WMH ratings below the 50 percentile. Conclusions: A history of CABG is an apparent risk factor for developing aMCI and dementia as well as for having higher WMH ratings. Those with CABG who had high WMH ratings had greater medial temporal atrophy, suggesting that there are related mechanisms for developing WMH and neurodegenerative disease among these subjects.